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Brief, high-intensity magnetic pulses are used to non-invasively stimulate specific areas of the brain, which can modulate neural activity and connectivity. Magnetic pulses work by creating electrical currents in the brain, which activate or inhibit neurons, depending on the frequency, timing and intensity of the pulses.
Magnetic pulses are a powerful tool for investigating brain function and treating neurological disorders. They are safe, painless, and have minimal side effects, making them a promising technology for the future of brain stimulation.
Non-invasive brain stimulation (NIBS) refers to a set of technologies to modulate the activity of the brain without invasive measures such as implants. Transcranial magnetic stimulation is one of the only NIBS technologies that is able to induce neural firing and not merely increase the likelihood of neural activity by using strong electromagnetic fields.
This is termed as suprathreshold stimulations as it induces an electrical field that passes the threshold needed for an action potential causing a neuron to fire. This property has enabled transcranial magnetic stimulation to foster higher clinical efficacy in neurological disorders than other non-invasive neuromodulation methods.
In the field of neuromodulation, it is difficult to separate the signal from the noise. We are committed to delivering the most clinically efficacious non-invasive brain stimulation which is why we chose to engineer the hard thing: brief, high-intensity, very focused magnetic pulses named transcranial magnetic stimulation. Suprathreshold, repetitive TMS has never been offered as a mobile solution before.
Unlike large, stationary machines that are typically limited to use in clinical settings, our portable devices can be easily transported to remote locations, making TMS therapy more accessible for patients in rural or underserved areas and accessible directly from the patients home. We aim to deliver the highest usability ever seen for transcranial magnetic stimulation so patients cannot only enjoy the effect but the therapy itself.
Every brain is unique. Therefore, it is only logical, that non-invasive brain stimulation protocols are adapted to the individual and their brain recording data. Our envisioned user-friendly design should enable longitudinal data collection to learn how brain waves are modified before, during and after stimulation. Thus, we can learn which modifications are best suited to the individual to personalize stimulation to your brain.
While we cannot disclose specific details of our proprietary technology, recent advancements in the field of neuroengineering have made it possible for us to enter the market with our innovative solutions. We are committed to staying at the forefront of this exciting field and leveraging the latest developments to push the boundaries of brain stimulation and improve neurological health.
We are the first to mobilize suprathreshold high-frequency TMS. This is an effective brain stimulation technology, which currently only exists in specialized hospitals, which currently requires patients to come in on a daily basis, to patients’ homes.
In addition, we are integrating our stimulation technology with simultaneous brain recordings to adapt stimulation protocols to the individual’s brain activity. Current transcranial magnetic stimulation does not utilize real-time brain recording data for more effective and personalized stimulation protocols.
Lastly, we are the first to continuously improve TMS protocols with real-time feedback from brain recordings and other biomarkers. This will enable us to learn from every use and optimize stimulation protocols to provide the most effective protocol with our unique solution.
Our headset learns from every application as it monitors your brain reaction. This allows to achieve higher efficacy, reduced variability, personalization and improvements over time. Every user contributes with their metadata to expand our knowledge/database with every application.
Our application targets a mechanism-of-action that trickles down from outer layers of the brain. It has been shown to be highly effective without the need to do surgery to implant a stimulation device, for which you need a cumbersome a way to power it. In addition, there are interesting advances for non-invasive-stimulations for deeper areas of the brain without reactions in areas you do not want to stimulate. It appears clear that the future belongs to non-invasive technologies.
We are superior to current neuromodulation solutions mainly due to two reasons: Firstly, our device will be based on TMS. This technology is basically seamless and thus trumps other technologies (like tDCS) with regards to UX. Moreover, it has been proven to be 5 to 9 times more effective than other technologies! Secondly, we integrate information from the individual i.e., we adapt stimulation to the brain’s reaction and predicted symptoms to achieve a more personalized stimulation with higher efficacy and reduced variability.
The other promising way than our suprathreshold TMS approach to cause neurons to fire is Deep-Brain-Stimulation (what Elon Musk is doing with Neuralink). Needless to say, that opening your skull has a lesser UX than what we do via magnetic fields from the outside.
Their benefit is to be closer to the neurons that need to be activated. This is a tradeoff in power needed and accuracy of stimulation.
Most neurological disorders suffer from poor solutions. We believe effective neuromodulation techniques can provide an alternative mechanism to tackle some of the greatest challenges to brain health. We start with migraine, here, in the EU and the US combined, 80 Million people are suffering from migraine. About 25% (or 20 Million) of them are dissatisfied with current treatment options, mainly due to insufficient pain relief, pain recurrence, or fear of side-effects. In short, we solve the literal pain point of migraine attacks while simultaneously widening the option space beyond pharmaceuticals by bringing neuromodulation headphones to the market you can acquire OTC (and get reimbursement by insurances).
Very recent findings in research demonstrated the potential of our technology. In addition, technology advanced in fields such as AI, dry-EEG and others that enable us to pull this off. In addition, current pharmaceutical solutions such as antibodies fail to deliver on the hopes put into them.
Thus, we are the first ones to act upon this potential.
Our CTO, Tamara learned about the potential of the closed-loop NIBS during her research at Prof. Adam Gazzaley’s lab at UCSF, which sparked the idea in her to make this powerful technology accessible to everyone. In 2022 she met our CEO Florian, who shared her passion and had worked in corporate finance and Med Tech consulting before. In September 2022 they founded the company and were able to acquire significant funding within weeks, which allowed them to establish the operations in Vienna and acquire a highly motivated and skilled team working on bringing the vision of effective neuromodulation for everyone to life!
We are planning our go-to-market with our medical device by the end of 2025 in the US. Beforehand, we are recruiting migraineurs to participate in our research studies to push the boundaries of effective migraine prevention.